FOLFIRI Regimen
Information
- Drug Name
- FOLFIRI Regimen
- Description
- Entry(CIViC)
- 1
CIViC
| Disease | Mutation | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| colorectal cancer |
PPP1R15A p.Arg251Pro (p.R251P) ( ENST00000200453.6, ENST00000600406.2, ENST00000704026.1, ENST00000704027.1 ) PPP1R15A p.Arg251Pro (p.R251P) ( ENST00000200453.6, ENST00000600406.2, ENST00000704026.1, ENST00000704027.1 ) |
B |
Predictive
|
Supports
|
Sensitivity/Response | Common Germline | 1 | 27177629 | Detail |
Annotation
| Description | Associated Genes | Associated Variants | Sensitivity | Supported | Source | Links |
|---|---|---|---|---|---|---|
| Exome and RNA sequencing was performed in tumor an... | PPP1R15A |
PPP1R15A p.Arg251Pro (p.R251P) ( ENST00000200453.6, ENST00000600406.2, ENST00000704026.1, ENST00000704027.1 ) PPP1R15A p.Arg251Pro (p.R251P) ( ENST00000200453.6, ENST00000600406.2, ENST00000704026.1, ENST00000704027.1 ) |
Sensitivity | true | CIViC Evidence | detail |
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT04793958 | Active, not recruiting | Phase 3 | Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10) | March 15, 2021 | February 28, 2026 |
| NCT03635021 | Active, not recruiting | Phase 3 | Study to Evaluate the Efficacy of FOLFOX + Panitumumab Followed by FOLFIRI + Bevacizumab (Sequence 1) Versus FOLFOX + Bevacizumab Followed by FOLFIRI + Panitumumab (Sequence 2) in Untreated Patients With Wild-type RAS Metastatic, Primary Left-sided, Unresectable Colorectal Cancer | October 15, 2018 | June 28, 2025 |
| NCT00005979 | Completed | Phase 3 | Combination Chemotherapy With or Without Irinotecan in Treating Patients With Stage III Colon Cancer | July 22, 1998 | September 1, 2007 |
| NCT00952029 | Completed | Phase 2/Phase 3 | Combination Chemotherapy and Bevacizumab With or Without Bevacizumab Maintenance Therapy in Treating Patients With Metastatic Colorectal Cancer | March 2010 | January 2018 |
| NCT01205711 | Completed | Phase 2 | Irinotecan Hydrochloride, Fluorouracil, and Leucovorin Calcium With or Without Zibotentan in Treating Patients With Metastatic Colorectal Cancer | April 2010 | September 2012 |
| NCT00008060 | Completed | Phase 3 | Combination Chemotherapy in Treating Patients With Unresectable Metastatic Colorectal Cancer | May 2000 | December 2003 |
| NCT00020488 | Completed | Phase 1 | Combination Chemotherapy in Treating Patients Who Have Advanced Solid Tumors | February 2001 | |
| NCT00440310 | Completed | Phase 3 | Phase 3 Trial of Litx™ Plus Chemotherapy vs. Chemotherapy Only Treating Colorectal Cancer Patients With Recurrent Liver Metastases | February 2007 | October 2011 |
| NCT00497497 | Completed | Phase 1 | A Study of PRO95780 in Combination With Cetuximab and Irinotecan Chemotherapy or the FOLFIRI Regimen With Bevacizumab in Patients With Previously Treated Metastatic Colorectal Cancer (APM4187g) | October 2007 | September 2010 |
| NCT00671372 | Completed | Phase 1 | A Study of Dulanermin Administered in Combination With Camptosar®/Erbitux® Chemotherapy or FOLFIRI (With or Without Bevacizumab) in Subjects With Previously Treated Metastatic Colorectal Cancer | July 2006 | March 2012 |
| NCT00020501 | Completed | Phase 3 | Chemotherapy With or Without Isolated Hepatic Perfusion With Melphalan in Treating Patients With Colorectal Cancer That Has Spread to the Liver | March 2001 | January 2005 |
| NCT00026273 | Completed | Phase 3 | Fluorouracil and Leucovorin With or Without Irinotecan in Treating Patients Following Surgery for Stage III Colorectal Cancer | January 2001 | |
| NCT00004885 | Completed | Phase 3 | Fluorouracil and Leucovorin With or Without Irinotecan in Treating Patients With Metastatic Colorectal Cancer | July 1999 | |
| NCT00064181 | Completed | Phase 3 | Combination Chemotherapy With or Without Celecoxib in Treating Patients With Metastatic Colorectal Cancer | May 2003 | |
| NCT00066274 | Completed | Phase 2 | Comparison of Combination Chemotherapy Regimens in Treating Patients With Metastatic Colorectal Cancer | July 23, 2002 | April 1, 2007 |
| NCT05193292 | Not yet recruiting | Phase 2 | Camrelizumab Combined With Trastuzumab and Chemotherapy in Patients With HER2-positive Advanced Colorectal Cancer | January 2022 | January 2025 |
| NCT06252649 | Not yet recruiting | Phase 3 | Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation | July 1, 2024 | December 30, 2030 |
| NCT04926545 | Recruiting | N/A | XCHT for Irinotecan-Induced Gut Toxicities (Run-in Study) | July 16, 2021 | October 31, 2024 |
| NCT05983367 | Recruiting | Phase 2 | A Study to Investigate Ompenaclid Combined With FOLFIRI Plus Bevacizumab in Advanced/Metastatic Colorectal Cancer | October 10, 2023 | August 2028 |
| NCT01937715 | Terminated | Phase 1/Phase 2 | A Study Of PF-05212384 Plus FOLFIRI Versus Bevacizumab Plus FOLFIRI In Metastatic Colorectal Cancer | February 2014 | August 2015 |
| NCT00023868 | Terminated | Phase 3 | Combination Chemotherapy With or Without Chemoembolization in Treating Patients With Colorectal Cancer Metastatic to the Liver (6655) | November 1, 2001 | September 25, 2002 |
| NCT00091312 | Unknown status | Phase 3 | Fluorouracil and Irinotecan With or Without Leucovorin Compared With Observation in Treating Patients Who Have Undergone Surgery for Stage II Colon Cancer | June 2004 | |
| NCT00005607 | Unknown status | Phase 2 | Combination Chemotherapy in Treating Patients With Metastatic or Recurrent Cancer of the Stomach or Esophagus | February 2000 | |
| NCT00006115 | Unknown status | Phase 2 | Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer | April 1999 | |
| NCT00021281 | Unknown status | Phase 3 | Combination Chemotherapy With or Without SU5416 in Treating Patients With Metastatic Colorectal Cancer | December 2000 | |
| NCT00027833 | Unknown status | Phase 2 | Vaccine Therapy and Chemotherapy With or Without Tetanus Toxoid Compared With Chemotherapy Alone in Treating Patients With Metastatic Colorectal Cancer | December 2001 | |
| NCT00075595 | Unknown status | Phase 2 | Fluorouracil, Leucovorin, and Irinotecan in Treating Patients With Recurrent or Refractory Metastatic Unresectable Colorectal Cancer | June 2002 | |
| NCT00003260 | Unknown status | Phase 3 | Combination Chemotherapy in Treating Patients With Recurrent Metastatic Colorectal Cancer | January 1998 | |
| NCT01167725 | Unknown status | Phase 3 | Standard Therapy With or Without Surgery and Mitomycin C in Treating Patients With Advanced Limited Peritoneal Dissemination of Colon Cancer | August 2010 | |
| NCT01736904 | Unknown status | Phase 2 | wXELIRI Versus FOLFIRI Regimen in the Treatment of Advanced Colorectal Cancer Patients | May 2012 | December 2015 |
| NCT00936832 | Withdrawn | Phase 2 | Sunitinib Malate and Combination Chemotherapy as Front-Line Therapy in Treating Patients With Metastatic Rectal Cancer That Cannot Be Removed by Surgery | April 2009 | March 24, 2010 |